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KMID : 1161420110140030209
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Journal of Medicinal Food
2011 Volume.14 No. 3 p.209 ~ p.218
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A Phellinus baumii Extract Reduces Obesity in High-Fat Diet-Fed Mice and Absorption of Triglyceride in Lipid-Loaded Mice
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Noh Jung-Ran
Lee In-Kyoung
Ly Sun-Yung
Yang Keum-Jin
Gang Gil-Tae
Kim Yong-Hoon
Hwang Jung-Hwan
Yun Bong-Sik
Lee Chul-Ho
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Abstract
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This study evaluated the anti-obesity effects of Phellinus baumii extract (PBE) in high-fat diet (HFD)-fed mice. Male 8-week-old C57BL/6 mice were randomly divided into four groups: control, normal chow diet plus vehicle; HFD-control, high-fat plus vehicle; HFD plus orlistat (Xenical®, Roche, Basel, Switzerland) (50?mg/kg); and HFD plus PBE (500?mg/kg). PBE was administered daily by oral gavage for 12 weeks. Oral administration of PBE (500?mg/kg) significantly reduced body weight gain, hepatic lipid concentrations, and fat accumulation in epididymal adipocytes compared with mice fed HFD alone (P?
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KEYWORD
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anti-obesity, hepatic lipid, Phellinus baumii, triglyceride absorption
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